SMTP ports can be unlocked account wide if you contact support and request it. After providing us with additional information in order to prove that you have valid reasons to run an email server. However, this verification process is getting stricter over time due to abuse of self managed email servers.
IP's are getting blacklisted and 67% of connected data centers are already within globally blocked IP ranges meaning that SMTP ports are completely blocked even if your account is unblocked.
The preferred solution is to use a managed email service from the list below: